. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: Magn Reson Med. 2017 Jul 16;78(3):1100–1109. doi: 10.1002/mrm.26820

Table 3.

Diagnostic Performance of Whole-tumor Histogram-based(Mean, 50^th percentile) and Multi-ROI-based (Maximum, Minimum)APTw Parameters in Predicting IDH Genotypes

Parameters	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95%CI)	NPV (95%CI)	Cut-off value (%)
Mean	0.75 (0.52–1)	0.57 (0.20–0.94)	1	1	0.87 (0.73–1.01)	1.58
50^th percentile	0.75 (0.49–1)	0.71 (0.38–1.05)	0.95 (0.85–1.05)	0.83 (0.54–1.13)	0.91 (0.78–1.03)	1.45
Maximum	0.89 (0.73–1)	0.57 (0.18–0.90)	1	1	0.87 (0.74–0.94)	1.67
Minimum	0.76 (0.51–1)	0.43 (0.10–0.82)	1	1	0.83 (0.72–0.90)	1.12

Note: AUC, area under the ROC curve; 95 %CI, 95 % confidence interval; PPV, positive predictive value; NPV, negative predictive value.