Table 2.
Baseline factors associated with HBeAg seroconversion.
| Univariate | Multivariate Model with qHBeAg | Multivariate Model with qHBsAg | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| RR | 95% CI | P values | RR | 95% CI | P values | RR | 95% CI | P values | |
| Sex | |||||||||
| Male | 1 | ||||||||
| Female | 0.54 | 0.08-3.58 | 0.52 | ||||||
| Age (per 10 years) | 1.35 | 0.90-2.01 | 0.14 | ||||||
| HBV-active cART | |||||||||
| 3TC -based | 1 | ||||||||
| TDF+3TC -based | 6.00 | 0.83-43.49 | 0.076 | ||||||
| CD4 cell count (per 100 cells/μl) | 1.30 | 0.85-2.00 | 0.22 | 1.63 | 1.00-2.67 | 0.050 | |||
| HIV RNA (per 1 log copies/ml) | 2.27 | 1.29-3.98 | 0.004 | 1.84 | 1.07-3.17 | 0.029 | 1.79 | 1.12-2.87 | 0.016 |
| HBV DNA | |||||||||
| ≥8 log IU/ml | 1 | ||||||||
| <8 log IU/ml | 2.00 | 0.67-5.94 | 0.21 | ||||||
| qHBeAg (per 1 log PEIU/ml) | 0.53 | 0.39-0.74 | <0.001 | 0.71 | 0.52-0.97 | 0.029 | |||
| qHBsAg (per 1 log IU/ml) | 0.27 | 0.12-0.61 | 0.002 | 0.26 | 0.13-0.51 | <0.001 | |||
| HBV genotype | |||||||||
| B | 1 | ||||||||
| C | 1.53 | 0.46-5.08 | 0.49 | ||||||
| Unknown | 0.87 | 0.11-6.69 | 0.89 | ||||||
| IL-18 (per 1 log pg/ml) | 3.16 | 1.23-8.11 | 0.017 | 2.99 | 1.08-8.29 | 0.035 | 3.71 | 1.18-11.65 | 0.025 |
| ALT>40 IU/l | 3.11 | 0.94-10.25 | 0.062 | 2.46 | 0.96-6.28 | 0.060 | |||
RR, relative risk; IQR, interquartile range; MSM, men who have sex with men; TDF, tenofovir disoproxil fumarate; 3TC, lamivudine; ALT, alanine transaminase; IU, international unit; qHBsAg, quantification of hepatitis B surface antigen; qHBeAg, quantification of hepatitis B e antigen; PEIU, Paul Ehrlich Institute unit; IL-18, interleukin-18.
Factors with P value<0.10 in the univariate model in addition to IL-18, CD4 cell count and HIV RNA were included in the initial multivariate models. Regression with backward stepwise elimination was built for this analysis. Variables with P>0.10 were eliminated in the stepwise elimination.