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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Neurosci Res. 2017 Mar 30;95(10):1951–1964. doi: 10.1002/jnr.24037

Figure 6. Top2b regulates key genes in photoreceptor transcriptional network.

Figure 6

Several key genes in the transcriptional network for photoreceptor development were recognized as Top2b-dependent genes (TDGs) by RNA-seq analysis. Coverage plots of Top2b (A), Crx (B), and Nr2e3 (C) show differential expression between control and Top2b cKO samples. The number of sequence reads mapped to their genes is plotted on their genomic locations. The maps of alternative spliced transcripts of these genes are also shown underneath the plot. (D) a schematic drawing of photoreceptor transcriptional network with Top2b as key modulator. Names of the down-regulated genes are shown in blue; up-regulated gene Vsx2 is in orange. Magenta lines indicate the effect of Top2b on those key genes.