Table 1.
Study population characteristics in discovery and validation panels (mean values (SD) for continuous variables and n (%) for categorical variables)
| Characteristics | Discovery panel | Validation panel | p value |
|---|---|---|---|
| N | 581 | 368 | |
| Age (years) | 61.0 (6.3) | 61.1 (6.4) | 0.809 |
| Sex (male) | 241 (41.5%) | 117 (31.8%) | < 0.001 |
| Smoking status | 0.864 | ||
| Current smoker | 108 (18.6%) | 65 (17.7%) | |
| Former smoker | 173 (29.8%) | 119 (32.3%) | |
| Never smoker | 300 (51.6%) | 184 (50.0%) | |
| Pack-years of smokinga | |||
| Current smokers | 34.6 (18.2) | 33.1 (18.2) | 0.250 |
| Former smokers | 22.0 (17.5) | 19.4 (15.5) | 0.033 |
| Smoking cessation time (years)b | 16.5 (11.3) | 17.2 (10.2) | 0.742 |
| Body mass indexc | 0.248 | ||
| Underweight or normal weight (< 25.0) | 143 (24.7%) | 116 (31.5%) | |
| Overweight (25.0–< 30.0) | 290 (50.2%) | 151 (41.0%) | |
| vObese (≥ 30.0) | 145 (25.1%) | 101 (27.5%) | |
| Alcohol consumptiond | 0.509 | ||
| Abstainer | 194 (36.3%) | 128 (38.0%) | |
| Low | 301 (56.4%) | 188 (55.8%) | |
| Intermediate | 30 (5.6%) | 17 (5.0%) | |
| High | 9 (1.7%) | 4 (1.2%) | |
| Physical activitye | 0.058 | ||
| Inactive | 109 (18.8%) | 82 (22.3%) | |
| Low | 245 (42.2%) | 176 (47.8%) | |
| Medium or high | 227 (39.0%) | 110 (29.9%) | |
| Prevalence of CVD at baselinef | 0.621 | ||
| Prevalent | 86 (14.8%) | 58 (15.8%) | |
| Prevalence of diabetes at baselineg | 0.617 | ||
| Prevalent | 86 (14.9%) | 60 (16.6%) | |
| Prevalence of cancer at baseline | |||
| Prevalent | 33 (5.7%) | 22 (6.0%) | 0.744 |
aFor subgroups of former and current smokers; data missing for 38 and 24 participants, respectively, in discovery and validation panels; a pack-year was defined as having smoked 20 cigarettes per day for 1 year
bFormer smokers only, data missing for 5 and 2 participants, respectively, in discovery and validation panels; cessation time equals age at recruitment minus age at cessation
cData missing for 3 participants in discovery panel
dData missing for 47 and 31 participants, respectively, in discovery and validation panels. Categories defined as follows: abstainer, low [women, 0–< 20 g/d; men, 0–< 40 g/d], intermediate [20–< 40 g/d and 40–< 60 g/d, respectively], high [≥ 40 g/d and ≥ 60 g/d, respectively]
eCategories defined as follows: inactive [< 1 h of physical activity/week], medium or high [≥ 2 h of vigorous or ≥ 2 h of light physical activity/week], low (other)
fCVD cardiovascular disease. Data missing for 1 participant in discovery panel
gData missing for 5 and 7 participants, respectively, in discovery and validation panels