Table 4.
Three most frequently identified mQTLs and corresponding CpG sites
| SNP | Chr | SNP positiona | Minor allele | MAFb | CpG | Distance (bp)c | FDRd |
|---|---|---|---|---|---|---|---|
| rs75509302 | 5 | 365,653 | C | 0.144 | cg23576855 | − 7647 | 3.4 e − 100 |
| cg11902777 | − 3190 | 1.4 e − 7 | |||||
| cg17287155 | − 27,694 | 7.8 e − 5 | |||||
| cg03991871 | − 2795 | 1.0 e − 4 | |||||
| cg12806681 | − 2742 | 1.2 e − 4 | |||||
| cg23916896 | − 3152 | 9.5 e − 4 | |||||
| cg03604011 | − 34,548 | 1.1 e − 3 | |||||
| cg14817490 | − 27,267 | 2.1 e − 3 | |||||
| rs34835481 | 1 | 92,991,624 | T | 0.210 | cg10399789 | 45,956 | 2.2 e − 5 |
| cg12876356 | 44,799 | 1.3 e − 3 | |||||
| cg09662411 | 45,492 | 1.9 e − 3 | |||||
| cg18146737 | 44,923 | 2.0 e − 3 | |||||
| cg18316974 | 44,589 | 3.0 e − 3 | |||||
| cg09935388 | 44,036 | 0.016 | |||||
| rs79050605 | 1 | 92,925,962 | G | 0.202 | cg12876356 | − 20,863 | 3.7 e − 4 |
| cg18146737 | − 20,739 | 1.1 e − 3 | |||||
| cg18316974 | − 21,073 | 1.7 e − 3 | |||||
| cg09662411 | − 20,170 | 1.9 e − 3 | |||||
| cg09935388 | − 21,626 | 2.2 e − 3 |
aSNPs positions were based on GRCh37/hg19
bMAF minor allele frequency
cThe distance between SNP and CpG (SNP position–CpG position)
dThe FDR-corrected p values of SNPs in fully adjusted mixed linear regression models, which controlled for age (years), sex, smoking status, random batch effect of methylation measurement, leukocyte distribution (Houseman algorithm), alcohol consumption (abstainer/low/intermediate/high), body mass index (BMI, underweight or normal weight/overweight/obese), physical activity (inactive/low/medium or high), prevalence of cardiovascular diseases (yes/no), prevalence of diabetes (yes/no), and prevalence of cancer (yes/no)