Table 1.
Basic information of included studies
| Study (years) | Species (Sex,n) | Model, anesthetic, weight | Interventions | Research methods |
|---|---|---|---|---|
| Virginia 2005 | SD Rats (Male,6/6) |
6-OHDA induced (12μg, s.i.), Isofiuorane,200 g |
Curcumin (50 mg/kg dissolve in 10% of Cremophor, gavage) for 4 days prior to lesioning |
1. IHC 2. HPLC analysis |
| Pan 2007 | C57BL/6 mice (Male,30/10) |
MPTP induced (30 mg/kg, i.p.), Pentobarbital, 20 g |
Curcumin (5, 50, 150 mg/kg dissolve in 1% DMSO, i.p., respectively) for 4 days after surgery |
1. IHC 2. WB analysis |
| Balusamy 2008 |
C57BL/6 mice (Male,6/6) |
BSO induced (3 mmol/kg, i.p.), NR, 25 g |
Curcumin (50 mg/kg dissolve in saline, i.p., bw per day, for 1 and 3 days) |
1. WB analysis |
| Rajeswari 2008 |
Swiss albino mice (Male, 8/8) |
MPTP induced (40 mg/kg, i.p.), NR, 25–30 g |
Curcumin (80 mg/kg dissolve in DMSO, i.p.) for 7 days after surgery |
1. HPLC analysis |
| Wang 2009 |
C57BL/6 mice (Male,10/10) |
MPTP induced (60 mg/kg, i.p.), NR, 25–30 g |
Curcumin (15 mg/kg dissolve in DMSO, i.p.) for 4 days prior to lesioning and after surgery | 1. RT-PCR 2. HPLC analysis |
| Song 2010 | C57BL/6 mice (Male,10/10) |
MPTP induced (30 mg/kg, i.p.), NR, 23–25 g |
Curcumin (50 mg/kg dissolve in DMSO, i.p.) for 5 days after surgery | 1. Behavioral tests and WB 2. IHC |
| Peng 2010 | SD Rats (Male,20/20) |
6-OHDA induced (16μg, s.i.), Pentobarbital, 200–250 g |
Curcumin (100 mg/kg dissolve in DMSO, gavage) for 4 weeks after surgery |
1. Behavioral tests 2. HPLC analysis |
| Zahra 2012 | Wister rats (Male,8/8) |
Homocysteine induced (2 mol/l, i.c.v.), NR, 250–300 g |
Curcumin (50 mg/kg dissolve in saline, i.p.) for 10 days beginning 5 days prior to Hcy injection |
1. Behavioral tests 2. IHC and Tunel staining |
| Du 2012 | Wister rats (Female,12/12) |
6-OHDA induced (20μg, s.i.), Chloral hydrate, 200–220 g |
Curcumin pretreatment (200 mg/kg dissolve in saline) twice a day for 24 days in total |
1. HPLC analysis 2. IHC |
| Yu 2012 | C57BL/6 mice (Male,10/10) |
MPTP induced (30 mg/kg, i.p.), NR, 25 g |
Curcumin (50 mg/kg dissolve in saline, i.p.) for 5 days after surgery |
1. Behavioral tests and WB 2. IHC and iron staining |
| Guo 2012 | C57BL/6 mice (Male,30/10) | Lipidosome induced (1 μg/ml, s.i.), Chloral hydrate, 18-22 g | Curcumin (10, 20, 40 mg/kg dissolve in 1% DMSO, respectively, i.p.) for 4 days after surgery | 1. Behavioral tests and WB 2. Elisa, RT-PCR, IFC 3. Luciferase assay |
| Tripanichkui 2013 | ICR strain mice (Male,7/7) | 6-OHDA induced (33μg, s.i.), Pentobarbital, NR | Curcumin (200 mg/kg dissolve in DMSO, i.p.) for 7 days after surgery | 1. IHC 2. Quantification Kits |
| Ariana 2014 | Swiss albino mice (Male, 16/8) | Inhalation Mn induced, NR, 45–55 g | Curcumin (500 or 1500 PPM) was supplemented in the diet for 14 weeks | 1. Behavioral tests 2. Neurochemical Analysis |
MPTP 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine; SD Rats Sprague-Dawley rats; BSO Buthionine sulfoximine; 6-OHDA 6-hydroxy dopamine; NR no report; s.i. Striatum injection; i.p. intraperitoneally; i.c.v. intracerebroventricularly; DMSO Dimethyl sulfoxide; PBS Phosphate-buffered saline; IHC Immunohistochemistry; HPLC High-performance liquid chromatography; WB analysis western blot; RT-PCR Reverse transcription-polymerase chain reaction; IFC immunofluorescence; Elisa the enzyme-linked immunosorbent assay