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. 2017 Aug 17;16:138. doi: 10.1186/s12943-017-0709-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of the lncRNA ABHD11 on in vivo tumor growth and metastasis ability as well as RhoC expression. The tumor xenograft volume in nude mice transfected with the lncRNA ABHD11-AS₁ was greater than that in the mock nude mice (a, b and c). Tumor xenograft growth in the ABHD11-AS₁-treated nude mice was faster than that in the control group (d). *P < 0.05. Macroscopic observation showed that the size and range of metastatic lesions were greater in the lncRNA ABHD11-AS₁-transfected nude mice (f). Immunohistochemical analysis demonstrated a significant increase in RhoC expression in the ABHD11-AS₁-transfected tumors compared with the control tumors both in the subcutaneously (e) and intraperitoneally injected nude mice (g). *P < 0.05