Table 5.
Cox proportional hazards model for multivariate analysis
| Characteristic | Overall survival
|
Disease-specific survival
|
||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| All osteosarcoma cases (n=648) | ||||
| Age | 1.03 (1.02–1.04) | <.001 | 1.02 (1.01–1.03) | <.001 |
| Race | 1.13 (0.90–1.42) | .310 | 1.11 (0.83–1.50) | .473 |
| Sex | 0.78 (0.57–1.07) | .124 | 0.80 (0.54–1.19) | .276 |
| Decade of diagnosis | 0.77 (0.59–0.99) | .049 | 0.83 (0.60–1.15) | .261 |
| Tumor subtype | 1.01 (0.91–1.12) | .918 | 1.04 (0.93–1.16) | .545 |
| Surgery | 0.55 (0.40–0.77) | <.001 | 0.46 (0.31–0.69) | <.001 |
| Radiation therapy | 1.48 (1.05–2.10) | .027 | 1.79 (1.17–2.73) | .007 |
| Size (cm) | 1.00 (0.98–1.03) | .784 | 1.01 (0.98–1.05) | .470 |
| Extent of disease | 2.49 (1.82–3.41) | <.001 | 2.34 (1.57–3.48) | <.001 |
| Osteosarcoma: 1990–2012 (n=501) | ||||
| Age | 1.02 (1.01–1.03) | <.001 | 1.02 (1.01–1.03) | <.001 |
| Race | 1.12 (0.89–1.41) | .317 | 1.10 (0.82–1.48) | .517 |
| Sex | 0.81 (0.58–1.12) | .205 | 0.82 (0.55–1.23) | .336 |
| Tumor subtype | 1.01 (0.91–1.12) | .824 | 1.04 (0.93–1.16) | .491 |
| Surgery | 0.53 (0.38–0.75) | <.001 | 0.45 (0.29–0.68) | <.001 |
| Radiation therapy | 1.49 (1.05–2.12) | .027 | 1.74 (1.13–2.66) | .012 |
| Size (cm) | 1.02 (0.99–1.05) | .202 | 1.02 (0.99–1.06) | .267 |
| Extent of disease | 2.32 (1.68–3.20) | <.001 | 2.23 (1.48–3.36) | <.001 |
| All Ewing sarcoma cases (n=736) | ||||
| Age | 1.03 (1.01–1.04) | <.001 | 1.03 (1.02–1.05) | <.001 |
| Race | 1.41 (1.08–1.83) | .011 | 1.50 (1.12–2.00) | .006 |
| Sex | 0.88 (0.65–1.21) | .432 | 0.91 (0.65–1.26) | .559 |
| Decade of diagnosis | 0.80 (0.61–1.03) | .085 | 0.81 (0.61–1.07) | .131 |
| Surgery | 0.69 (0.49–0.96) | .030 | 0.72 (0.50–1.02) | .064 |
| Radiation therapy | 0.78 (0.57–1.08) | .139 | 0.82 (0.58–1.15) | .238 |
| Size (cm) | 1.05 (1.03–1.08) | <.001 | 1.05 (1.02–1.08) | <.001 |
| Extent of disease | 2.72 (2.00–3.70) | <.001 | 2.67 (1.94–3.68) | <.001 |
| Ewing sarcoma: 1990–2012 (n=596) | ||||
| Age | 1.02 (1.01–1.04) | <.001 | 1.03 (1.02–1.05) | <.001 |
| Race | 1.40 (1.06–1.84) | .017 | 1.57 (1.17–2.11) | .003 |
| Sex | 0.87 (0.63–1.20) | .394 | 0.87 (0.63–1.22) | .431 |
| Surgery | 0.64 (0.45–0.91) | .012 | 0.69 (0.48–0.99) | .046 |
| Radiation therapy | 0.76 (0.54–1.07) | .113 | 0.76 (0.54–1.08) | .126 |
| Size (cm) | 1.05 (1.02–1.09) | .002 | 1.05 (1.01–1.08) | .011 |
| Extent of disease | 2.56 (1.87–3.51) | <.001 | 2.59 (1.87–3.58) | <.001 |
CI, confidence interval; HR, hazard ratio.