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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Exp Neurol. 2017 Jun 3;295:162–175. doi: 10.1016/j.expneurol.2017.06.005

Figure 4. Increased ACh levels in TorA+/+ mice drive the D2R paradoxical excitation of ChI firing through mAChR activation.

Figure 4

(A) Increase in ChI firing rate induced by the D2R agonist Quin (10 µM) in the presence of the AChE inhibitor Neo (100nM). n=10, 4 animals * p< 0.05, **p< 0.005, RM one-way ANOVA) and (B) in the presence of a mAChR agonist (Oxo 1µM, n=10 cells, 5 animals * p< 0.05, RM one-way ANOVA). (C) Quin does not induce the paradoxical excitation of ChI firing in the presence of Oxo and the D2Rs antagonist sulpiride (3 µM, n=11, 4 animals **p< 0.005, RM one-way ANOVA). (1) Time course of firing rate change; symbols represent mean ± SEM, (2) summary bar chart of % of change, (3) example traces of spontaneous firing, (4) inter-spike intervals (ISI) cumulative distribution and (5) box plot summary of the change in the coefficient of variation (CV) of the ISI frequency histograms.