(A) Increase in ChI firing rate induced by the D2R agonist Quin (10 µM) in the presence of the AChE inhibitor Neo (100nM). n=10, 4 animals * p< 0.05, **p< 0.005, RM one-way ANOVA) and (B) in the presence of a mAChR agonist (Oxo 1µM, n=10 cells, 5 animals * p< 0.05, RM one-way ANOVA). (C) Quin does not induce the paradoxical excitation of ChI firing in the presence of Oxo and the D2Rs antagonist sulpiride (3 µM, n=11, 4 animals **p< 0.005, RM one-way ANOVA). (1) Time course of firing rate change; symbols represent mean ± SEM, (2) summary bar chart of % of change, (3) example traces of spontaneous firing, (4) inter-spike intervals (ISI) cumulative distribution and (5) box plot summary of the change in the coefficient of variation (CV) of the ISI frequency histograms.