Table V.
Significantly enriched Gene Ontology and pathways of blastocysts between in IVM group vs. in vivo group.
| GO/Pathway ID | Regulation direction | Count | Description | Gene symbols |
|---|---|---|---|---|
| GO:0015711 | Up | 9 | Organic anion transport | PQLC2, PRAF2, SLC38A6, GRM7, SLC26A6, ABCB11, SLC15A4, MFSD10, SCP2 |
| GO:0000096 | Up | 3 | Sulfur amino acid metabolic process | GCLM, COMT, MAT2A |
| GO:0034754 | Up | 4 | Cellular hormone metabolic process | SCP2, HSD17B3, DHRS9, COMT |
| GO:0032259 | Up | 5 | Methylation | ZNF335, CMTR2, COMT, MAT2A, PRDM15 |
| GO:0043523 | Up | 4 | Regulation of neuron apoptotic process | GCLM, LRP1, BCL2L11, FOXO3 |
| hsa00270 | Up | 2 | Cysteine and methionine metabolism | MAT2A, SRM |
| hsa00480 | Up | 2 | Glutathione metabolism | GCLM, SRM |
| hsa04978 | Up | 2 | Mineral absorption | MT1A, SLC26A6 |
| hsa00140 | Up | 2 | Steroid hormone biosynthesis | COMT, HSD17B3 |
| GO:0030178 | Down | 6 | Negative regulation of Wnt signaling pathway | G3BP1, MAD2L2, NPHP4, SHH, STK4, GNB2L1 |
| GO:0090090 | Down | 5 | Negative regulation of canonical Wnt signaling pathway | G3BP1, MAD2L2, NPHP4, SHH, STK4 |
| GO:0035329 | Down | 3 | Hippo signaling | NPHP4, STK4, TEAD3 |
| GO:0021510 | Down | 5 | Spinal cord development | SHH, MDGA2, MDGA1, EVX1, NEUROG3 |
Pathway IDs were produced from KEGG analysis. Count indicates the number of differentially expressed genes associated with the listed GO/pathway ID. IVM, in vitro maturation; GO, gene ontology.