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. 2017 Jun 14;16(2):1826–1836. doi: 10.3892/mmr.2017.6773

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Copyright: © Park et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effects of HA on the MAPK/ERK signaling pathway in EGF-activated ovarian cancer cells. Expression of Ras/Raf/MEK signaling molecules and sequential activation of MAPK following treatment with HA in EGF-activated (A) SK-OV-3 and (B) Caov-3 cells. Densitometry values of MAPK and MEK proteins were normalized to the total MAPK and MEK protein in the same sample. Densitometry values of Ras and Raf proteins were normalized to β-actin in the same sample. Data are expressed as the mean ± standard error of the mean. ***P<0.001 vs. non-HA-treated C group; ^#P<0.05 vs. non-HA-treated E group. C, control group; D, DMSO group; E, EGF-treated group; So, sorafenib-treated group; So + E, sorafenib- and EGF-treated group; HA, hyaluronan; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; EGF, epidermal growth factor; MEK, MAPK/ERK kinase; JNK, c-Jun N-terminal kinase; p-, phosphorylated.