Table II.
Proteins with statistically significant differential expression between the control and 14th day groups.
| Accession | Peptides | P-valuea | Fold changesa | Description | Function |
|---|---|---|---|---|---|
| RS7_RAT | 1 | 7.86×10−3 | 757.53 | 40S ribosomal protein S7 | |
| SUCA_RAT | 3 (2) | 3.10×10−5 | 64.97 | Succinyl-CoA ligase [ADP/GDP-forming] subunit α | Oxidoreductase |
| STIM1_RAT | 6 (1) | 8.62×10−6 | 7.94 | Stromal interaction molecule 1 | |
| PER1_RAT | 6 (1) | 3.17×10−3 | 7.51 | Period circadian protein homolog 1 | Transcription cofactor |
| ERAP1_RAT | 6 (1) | 1.25×10−3 | 6.7 | Endoplasmic reticulum aminopeptidase 1 | Metalloprotease |
| P97573 | 9 (3) | 0.01 | 6.47 | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 | Phosphatase |
| PALM_RAT | 4 (1) | 0.03 | 5.93 | Paralemmin-1 | |
| MDHM_RAT | 7 (2) | 0.03 | 5.43 | Malate dehydrogenase | Dehydrogenase |
| ES1_RAT | 3 (2) | 4.24×10−3 | 3.71 | ES1 protein homolog | |
| ACON_RAT | 8 (3) | 2.04×10−3 | 3.48 | Aconitate hydratase | Dehydrogenase |
| ODPA_RAT | 5 (3) | 9.40×10−4 | 3.02 | Pyruvate dehydrogenase E1 component subunit α, somatic form | Dehydrogenase |
| 3HIDH_RAT | 3 (2) | 0.05 | 2.91 | 3-hydroxyisobutyrate dehydrogenase | Dehydrogenase |
| H31_RAT | 5 (2) | 1.29×10−3 | 2.85 | Histone H3.1 | |
| DESM_RAT | 7 (3) | 0.01 | 2.83 | Desmin | Structural protein |
| KCRS_RAT | 9 (3) | 5.03×10−4 | 2.81 | Creatine kinase S-type | Amino acid kinase |
| DHSD_RAT | 1 | 1.09×10−3 | 2.74 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit | |
| FUMH_RAT | 11 (4) | 0.01 | 2.71 | Fumarate hydratase | Lyase |
| CH60_RAT | 3 (1) | 0.01 | 2.64 | 60 kDa heat shock protein | Chaperonin |
| ITB1_RAT | 7 (4) | 0.01 | 2.52 | Integrin β-1 | |
| SMC3_RAT | 25 (4) | 2.99×10−4 | 2.43 | Structural maintenance of chromosomes protein 3 | |
| THIOM_RAT | 2 (1) | 0.04 | 2.4 | Thioredoxin | |
| ATPO_RAT | 9 (5) | 3.86×10−3 | 2.39 | ATP synthase subunit Ol | ATP synthase |
| GRP75_RAT | 16 (3) | 0.03 | 2.34 | Stress-70 protein | |
| ACADL_RAT | 8 (4) | 7.38×10−3 | 2.3 | Long-chain specific acyl-CoA dehydrogenase | Transferase |
| ALDH2_RAT | 7 (3) | 0.03 | 2.28 | Aldehyde dehydrogenase | |
| ATP5E_RAT | 2 (1) | 5.64×10−3 | 2.19 | ATP synthase subunit epsilon | ATP synthase |
| ATPB_RAT | 4 (3) | 7.99×10−4 | 2.14 | ATP synthase subunit β | ATP synthase |
| ECHM_RAT | 4 (1) | 2.97×10−3 | 2.1 | Enoyl-CoA hydratase | Acetyltransferase |
| MAVS_RAT | 2 | 0.03 | 2.02 | Mitochondrial antiviral-signaling protein | |
| ANXA6_RAT | 10 (7) | 1.92×10−5 | −2.07 | Annexin A6 | |
| SPA3N_RAT | 2 (1) | 0.02 | −2.08 | Serine protease inhibitor A3N | Serine protease inhibitor |
| PSB1_RAT | 3 (2) | 1.83×10−3 | −2.1 | Proteasome subunit β type-1 | Protease |
| PGK1_RAT | 9 (3) | 2.47×10−4 | −2.16 | Phosphoglycerate kinase 1 | Carbohydrate kinase |
| RL26_RAT | 4 (1) | 9.18×10−4 | −2.24 | 60S ribosomal protein L26 | Ribosomal protein |
| CDK7_RAT | 5 (2) | 0.01 | −2.25 | Cyclin-dependent kinase 7 (Fragment) | Non-receptor serine/threonine protein kinase |
| FINC_RAT | 9 (6) | 3.50×10−3 | −2.28 | Fibronectin | Signaling molecule |
| CHD8_RAT | 8 (2) | 1.55×10−3 | −2.31 | Chromodomain-helicase-DNA-binding protein 8 | DNA helicase |
| CDS2_RAT | 1 | 0.03 | −2.46 | Phosphatidate cytidylyltransferase 2 | Nucleotidyltransferase |
| MYH7_RAT | 101 (17) | 9.06×10−6 | −2.48 | Myosin-7 | G-protein modulator |
| APOH_RAT | 1 | 1.44×10−3 | −2.53 | β-2-glycoprotein 1 | Apolipoprotein |
| IGG2B_RAT | 2 | 6.88×10−3 | −2.56 | Ig γ-2B chain C region | |
| PABP1_RAT | 7 (1) | 9.54×10−5 | −2.77 | Polyadenylate-binding protein 1 | Transcription factor |
| SELS_RAT | 3 (1) | 5.32×10−3 | −2.78 | Selenoprotein S | |
| KACA_RAT | 1 | 3.62×10−5 | −2.87 | Ig κ chain C region, A allele | |
| PPIB_RAT | 3 (1) | 0.02 | −2.88 | Peptidyl-prolyl cis-trans isomerase B | Isomerase |
| P06399 | 36 (10) | 3.00×10−6 | −2.88 | Fibrinogen α chain | |
| HSDL2_RAT | 6 (1) | 7.17×10−3 | −2.9 | Hydroxysteroid dehydrogenase-like protein 2 | Dehydrogenase |
| DJC14_RAT | 5 (2) | 5.49×10−4 | −2.98 | Dnaj homolog | Chaperone |
| C4BPA_RAT | 6 (3) | 8.39×10−3 | −3.02 | C4b-binding protein α chain | Apolipoprotein |
| EXOC8_RAT | 6 (1) | 2.70×10−3 | −3.09 | Exocyst complex component 8 | |
| GDIB_RAT | 3 (1) | 1.76×10−4 | −3.12 | Rab GDP dissociation inhibitor β | Acyltransferase |
| NDUA9_RAT | 3 (2) | 6.17×10−4 | −3.2 | NADH dehydrogenase [ubiquinone] 1 α subcomplex subunit 9 | Dehydrogenase |
| MVP_RAT | 4 (2) | 1.37×10−3 | −3.26 | Major vault protein | Ribonucleoprotein |
| S10A3_RAT | 1 | 1.41×10−3 | −3.28 | Protein S100-A3 | Calmodulin |
| HBB2_RAT | 5 (1) | 7.25×10−3 | −3.58 | Hemoglobin subunit β-2 | |
| FIBB_RAT | 10 (6) | 1.68×10−4 | −3.75 | Fibrinogen β chain | Signaling molecule |
| CEP41_RAT | 4 (1) | 4.12×10−4 | −3.9 | Centrosomal protein of 41 kDa | |
| AT5F1_RAT | 3 (1) | 0.01 | −3.93 | ATP synthase subunit b, mitochondrial | |
| GRM4_RAT | 5 (2) | 6.43×10−5 | −4.01 | Metabotropic glutamate receptor 4 | G-protein coupled receptor |
| PRELP_RAT | 4 (1) | 1.31×10−3 | −4.03 | Prolargin | Extracellular matrix protein |
| FIBG_RAT | 8 (4) | 8.81×10−5 | −4.18 | Fibrinogen γ chain OS | Signaling molecule |
| IGG2A_RAT | 4 (1) | 2.06×10−3 | −4.76 | Ig γ-2A chain C region | |
| HEMO_RAT | 6 (2) | 1.10×10−3 | −4.84 | Hemopexin | Transfer/carrier protein |
| LSG1_RAT | 4 (1) | 5.76×10−6 | −4.84 | Large subunit GTPase 1 homolog | Signaling molecule |
| ZBT38_RAT | 11 (2) | 1.86×10−3 | −5.56 | Zinc finger and BTB domain-containing protein 38 | KRAB box transcription factor |
| RL10A_RAT | 5 (1) | 3.82×10−4 | −5.64 | 60S ribosomal protein L10a | Ribosomal protein |
| PGS2_RAT | 4 (1) | 6.25×10−6 | −5.7 | Decorin | Extracellular matrix protein |
| KNT1_RAT | 3 (1) | 1.71×10−3 | −5.96 | T-kininogen 1 | |
| IGHG1_RAT | 3 (1) | 5.69×10−5 | −6.37 | Ig γ-1 chain C region | |
| PTGIS_RAT | 9 (3) | 2.05×10−5 | −6.76 | Prostacyclin synthase | Oxidoreductase |
| CAC1D_RAT | 7 (1) | 3.56×10−3 | −7.46 | Voltage-dependent L-type calcium channel subunit α-1D | Voltage-gated calcium channel |
| ECI1_RAT | 4 (1) | 0.04 | 9.73 | Enoyl-CoA ∆ isomerase 1 | Acetyltransferase |
| KNT2_RAT | 3 (1) | 1.41×10−4 | −16.47 | T-kininogen 2 | |
| RS13_RAT | 2 (1) | 1.04×10−3 | −23.58 | 40S ribosomal protein S13 | Ribosomal protein |
| SPRY4_RAT | 3 (1) | 0.04 | −28.28 | Sprydomain-containing protein 4 | |
| LEG3_RAT | 2 (1) | 6.19×10−6 | −36.14 | Galectin-3 | Signaling molecule |
| PRP19_RAT | 3 (1) | 0.02 | −68.84 | Pre-mRNA-processing factor 19 | mRNA splicing factor |
| HD_RAT | 17 (1) | 5.69×10−3 | −366.94 | Huntingtin, subfamily C member 14 |
a
Control vs. 14th day group. Control group, operation with no occlusion (untreated); 14th day group, tissues were taken from rats 14 days following surgical procedures. The numbers in brackets represent the number of peptides involved in the quantitative analysis.