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Effect of eculizumab (anti-C5) and ACH-4471 (a complement factor D inhibitor) on complement pathways. (A,C) CP activity measured by CP Wieslab. (B,D) CP activity measured by hemolytic assay. Horizontal dashed lines represent IC50, which was 18.3 µg/mL for eculizumab. (E) AP activity measured by AP Wieslab assay. At a concentration of 1 µM ACH-4471 (0.58 µg/mL), complete inhibition was achieved.
