Figure 1.

BMP-7 facilitates wound healing and prevents scar formation in a mouse model of thermal injury. (A) The model was first established and mice were subcutaneously injected with saline or 25, 50 or 100 µg BMP-7. At 0, 3, 7, 10 and 14 days following thermal injury, photos of mice from each group were obtained and the representative images are presented. (B) The average wound area of mice in each group was calculated, and the percentage wound area relative to the area at day 0 is presented. The results are presented as the mean + standard deviation (n=6), and are representative of three independent experiments. ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. untreated thermal injury group. BMP-7, bone morphogenetic protein-7.