Table I.
Characteristics of subjects included in the meta-analysis of interleukin-4 rs2243250 polymorphism and cancer risk.
| Case | Control | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First author, year | Country | Ethnicity | Cancer type | n | Genotypes CC/CT/TT | Alleles C/T (%) | n | Genotypes CC/CT/TT | Alleles C/T (%) | P-value HWE | NOS score | (Refs.) |
| Amirzargar, 2005 | Iran | Caucasian | Leukemia | 30 | 13/17/0 | 71.7/28.3 | 40 | 5/35/0 | 56.3/43.7 | <0.001 | 7 | (42) |
| Andrie, 2009 | Greece | Caucasian | Lymphoma | 85 | 66/17/2 | 87.6/12.4 | 85 | 70/14/1 | 90.6/9.6 | 0.753 | 7 | (26) |
| Chang, 2015 | Taiwan | Asian | Lung cancer | 358 | 247/95/16 | 82.3/17.7 | 716 | 439/218/59 | 76.5/23.5 | <0.001 | 7 | (35) |
| Chen, 2016 | China | Asian | Prostate cancer | 439 | 46/171/222 | 30.0/70.0 | 524 | 29/173/322 | 22.0/78.0 | 0.368 | 7 | (22) |
| Chu, 2012 | China | Asian | Bladder cancer | 816 | 39/264/513 | 21.0/79.0 | 1140 | 46/393/701 | 21.3/78.7 | 0.322 | 7 | (41) |
| Chu, 2012 | China | Asian | Renal cell carcinoma | 620 | 22/189/409 | 18.8/81.2 | 623 | 36/195/392 | 21.4/78.6 | 0.079 | 7 | (18) |
| Cozar, 2007 | Spain | Caucasian | Renal cell carcinoma | 127 | 93/30/4 | 85.0/15.0 | 174 | 123/47/4 | 84.2/15.8 | 0.844 | 7 | (19) |
| Cozar, 2007 | Spain | Caucasian | Colorectal cancer | 96 | 68/25/3 | 83.9/16.1 | 174 | 123/47/4 | 84.2/15.8 | 0.844 | 7 | (19) |
| Crusius, 2008 | Netherlands | Caucasian | Gastric cancer | 242 | 159/76/7 | 81.4/18.6 | 1154 | 824/305/25 | 84.6/15.4 | 0.603 | 7 | (11) |
| El-omar, 2003 | Scotland | Mixed | Esophageal cancer | 90 | 55/28/7 | 76.7/23.3 | 209 | 153/46/10 | 84.2/15.8 | 0.013 | 7 | (12) |
| El-omar, 2003 | Scotland | Mixed | Gastric cancer | 122 | 78/37/7 | 79.1/20.9 | 209 | 153/46/10 | 84.2/15.8 | 0.013 | 7 | (12) |
| Garcia-Gonzalez, 2007 | Spain | Caucasian | Gastric cancer | 404 | 283/107/14 | 83.3/16.7 | 404 | 267/123/14 | 81.3/18.7 | 0.971 | 8 | (13) |
| Gaur, 2011 | India | Caucasian | Oral carcinoma | 140 | 18/55/67 | 32.5/67.5 | 120 | 9/35/76 | 22.1/77.9 | 0.095 | 8 | (28) |
| Gu, 2014 | China | Asian | Lung cancer | 500 | 22/157/321 | 20.1/79.9 | 500 | 15/161/324 | 19.1/80.9 | 0.348 | 7 | (34) |
| Howell, 2003 | UK | Caucasian | Skin cancer | 153 | 130/23/0 | 92.5/7.5 | 208 | 165/39/4 | 88.7/11.3 | 0.352 | 8 | (25) |
| Joshi, 2014 | India | Caucasian | Breast cancer | 163 | 120/39/4 | 85.6/14.4 | 224 | 144/72/8 | 80.4/19.6 | 0.786 | 8 | (20) |
| Lai, 2005 | Taiwan | Asian | Gastric cancer | 123 | 2/38/83 | 17.1/82.9 | 162 | 7/50/105 | 19.8/80.2 | 0.736 | 7 | (14) |
| Li, 2012 | China | Asian | Lung cancer | 1072 | 54/280/738 | 18.1/81.9 | 1126 | 94/341/691 | 23.5/76.5 | <0.001 | 7 | (33) |
| Liang, 2010 | China | Asian | Gastric cancer | 238 | 10/53/175 | 15.3/84.7 | 112 | 6/28/78 | 17.9/82.1 | 0.118 | 7 | (17) |
| Lu, 2014 | China | Asian | Hepatocellular cancer | 154 | 4/39/111 | 15.3/84.7 | 170 | 4/51/115 | 17.4/82.6 | 0.055 | 7 | (31) |
| Monroy, 2011 | USA | Mixed | Lymphoma | 100 | 69/27/4 | 82.5/17.5 | 100 | 67/24/9 | 79.0/21.0 | 0.006 | 7 | (27) |
| Olson, 2007 | USA | Mixed | Prostate cancer | 149 | 101/39/9 | 80.9/19.1 | 128 | 96/26/6 | 85.2/14.8 | 0.026 | 7 | (23) |
| Pan, 2014 | China | Asian | Gastric cancer | 308 | 39/69/200 | 23.9/76.1 | 307 | 9/100/198 | 19.2/80.8 | 0.390 | 7 | (15) |
| Purdue, 2007 | USA | Mixed | Testicular germ cell tumor | 506 | 363/133/10 | 84.9/15.1 | 606 | 450/143/13 | 86.1/13.9 | 0.680 | 8 | (40) |
| Saxena, 2014 | India | Caucasian | Hepatocellular carcinoma | 59 | 16/40/3 | 61.0/39.0 | 153 | 58/88/7 | 66.7/33.3 | <0.001 | 7 | (32) |
| Schonfeld, 2010 | USA | Mixed | Breast cancer | 838 | 616/206/16 | 85.8/14.2 | 1074 | 750/289/35 | 83.3/16.7 | 0.273 | 8 | (21) |
| Suchy, 2008 | Poland | Caucasian | Colorectal cancer | 350 | 225/113/12 | 80.4/19.6 | 350 | 230/107/13 | 81.0/19.0 | 0.899 | 8 | (36) |
| Tsai, 2005 | Taiwan | Asian | Oral carcinoma | 130 | 9/21/100 | 15.0/85.0 | 105 | 2/28/75 | 15.2/84.8 | 0.741 | 7 | (29) |
| Vairaktaris, 2008 | Greek and German | Caucasian | Oral carcinoma | 156 | 84/46/26 | 68.6/31.4 | 162 | 99/48/15 | 75.9/24.1 | 0.016 | 7 | (30) |
| Welsh, 2011 | UK | Caucasian | Skin cancer | 892 | 675/197/20 | 86.6/13.3 | 801 | 608/174/19 | 86.8/13.2 | 0.126 | 8 | (24) |
| Wiemels, 2007 | USA | Mixed | Glioma | 384 | 278/95/11 | 84.8/15.2 | 468 | 313/144/11 | 82.3/17.7 | 0.239 | 8 | (39) |
| Wilkening, 2008 | North Sweden | Caucasian | Colorectal cancer | 304 | 183/104/17 | 77.3/22.7 | 582 | 339/200/43 | 75.4/24.6 | 0.079 | 8 | (37) |
| Yang, 2014 | Taiwan | Asian | Oral carcinoma | 463 | 13/148/302 | 18.8/81.2 | 623 | 23/218/382 | 21.2/78.8 | 0.233 | 7 | (53) |
| Yang, 2014 | Taiwan | Asian | Pharyngeal carcinoma | 129 | 4/43/82 | 19.8/80.2 | 623 | 23/218/382 | 21.2/78.8 | 0.233 | 7 | (53) |
| Yannopoulos, 2007 | Greece | Caucasian | Colorectal cancer | 93 | 73/15/5 | 86.6/13.4 | 108 | 69/30/9 | 77.8/22.2 | 0.041 | 7 | (38) |
| Zambon, 2008 | Italy | Caucasian | Gastric cancer | 40 | 32/7/1 | 88.8/11.2 | 64 | 45/17/2 | 83.6/16.4 | 0.800 | 7 | (16) |
Significant associations are denoted in bold font. HWE, Hardy-Weinberg equilibrium; NOS, Newcastle-Ottawa quality assessment scale.