Table III.
Characteristics of subjects included in the meta-analysis of inteleukin-4 rs2070874 polymorphism and cancer risk.
| Case | Control | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First author, year | Country | Ethnicity | Cancer type | n | Genotypes CC/CT/TT | Alleles C/T (%) | n | Genotypes CC/CT/TT | Alleles C/T (%) | P-value HWE | NOS score | (Ref.) |
| Amirzargar, 2005 | Iran | Caucasian | Leukemia | 30 | 20/5/5 | 75.0/25.0 | 40 | 22/18/0 | 77.5/22.5 | 0.066 | 7 | (42) |
| Chang, 2015 | Taiwan | Asian | Lung cancer | 358 | 238/101/19 | 80.6/19.4 | 716 | 453/223/40 | 78.8/21.2 | 0.075 | 7 | (35) |
| Crusius, 2008 | Netherlands | Caucasian | Gastric cancer | 243 | 159/77/7 | 81.3/18.7 | 1160 | 839/296/25 | 85.1/14.9 | 0.853 | 8 | (11) |
| Gaur, 2011 | India | Caucasian | Oral carcinoma | 140 | 20/61/59 | 36.1/63.9 | 120 | 11/38/71 | 25.0/75.0 | 0.088 | 8 | (28) |
| Gu, 2008 | USA | Mixed | Skin cancer | 217 | 160/52/5 | 85.7/14.3 | 214 | 165/43/6 | 87.1/12.9 | 0.132 | 8 | (45) |
| Lu, 2010 | China | Asian | Gastric cancer | 1042 | 27/271/744 | 15.6/84.4 | 1099 | 24/332/743 | 17.3/82.7 | 0.062 | 7 | (44) |
| Lu, 2014 | China | Asian | Hepatocellular cancer | 135 | 8/43/84 | 21.9/78.1 | 147 | 4/45/98 | 18.0/82.0 | 0.664 | 7 | (31) |
| Purdue, 2007 | USA | Mixed | Testicular germ cell tumor | 501 | 364/128/9 | 85.4/14.6 | 598 | 447/139/12 | 86.4/13.6 | 0.757 | 8 | (40) |
| Schonfeld, 2010 | USA | Mixed | Breast cancer | 818 | 600/206/12 | 85.9/14.1 | 1081 | 763/288/30 | 83.9/16.1 | 0.654 | 7 | (21) |
| Shamran, 2014 | Iraq | Caucasian | Brain tumor | 100 | 71/26/3 | 84.0/16.0 | 40 | 22/13/5 | 71.3/28.7 | 0.191 | 8 | (43) |
| Wiemels, 2007 | USA | Mixed | Brain tumor | 386 | 281/93/12 | 84.8/15.2 | 471 | 328/134/9 | 83.9/16.1 | 0.267 | 8 | (39) |
Significant associations are denoted in bold font. HWE, Hardy-Weinberg equilibrium; NOS, Newcastle-Ottawa quality assessment scale.