Table IV.
Subgroup analyses for interleukin-4 rs2070874polymorphism and cancer risk.
| A, Gastric cancer (n=3a) | ||||
|---|---|---|---|---|
| Variable | P-value | OR (95% Cl) | I-square (%) | P-value for the heterogeneity |
| CC vs. CT | 0.91 | 1.03 (0.60–1.76) | 59% | 0.09 |
| CT vs. TT | 0.07 | 0.85 (0.71–1.01) | 0% | 0.52 |
| TT vs. CC | 0.67 | 0.91 (0.59–1.41) | 25% | 0.26 |
| CC vs. CT + TT | 0.94 | 1.02 (0.60–1.74) | 60% | 0.08 |
| CT vs. CC + TT | 0.85 | 1.04 (0.72–1.49) | 75% | 0.85 |
| TT vs. CC + CT | 0.11 | 1.15 (0.97–1.36) | 5% | 0.35 |
| C vs. T | 0.35 | 0.90 (0.72–1.12) | 53% | 0.12 |
| B, Brain tumor (n=2a) | ||||
| CC vs. CT | 0.10 | 1.27 (0.95–1.70) | 0% | 0.55 |
| CT vs. TT | 0.86 | 1.17 (0.19–7.13) | 75% | 0.05 |
| TT vs. CC | 0.62 | 0.59 (0.07–4.70) | 82% | 0.02 |
| CC vs. CT + TT | 0.11 | 1.25 (0.95–1.65) | 41% | 0.19 |
| CT vs. CC + TT | 0.30 | 0.52 (0.15–1.77) | 78% | 0.03 |
| TT vs. CC + CT | 0.67 | 0.65 (0.09–4.74) | 81% | 0.02 |
| C vs. T | 0.29 | 1.42 (0.74–2.73) | 75% | 0.05 |
| C, Leukemia (n=1a) | ||||
| CC vs. CT | 0.05 | 3.27 (1.02–10.45) | NA | NA |
| CT vs. TT | 0.02 | 0.03 (0.00–0.57) | NA | NA |
| TT vs. CC | 0.10 | 12.07 (0.63–232.12) | NA | NA |
| CC vs. CT + TT | 0.33 | 1.64 (0.61–4.37) | NA | NA |
| CT vs. CC + TT | 0.02 | 0.24 (0.08–0.77) | NA | NA |
| TT vs. CC + CT | 0.06 | 17.47 (0.93–329.53) | NA | NA |
| C vs. T | 0.73 | 0.87 (0.40–1.91) | NA | NA |
| D, Lung cancer (n=1a) | ||||
| CC vs. CT | 0.30 | 1.16 (0.87–1.54) | NA | NA |
| CT vs. TT | 0.88 | 0.95 (0.53–1.73) | NA | NA |
| TT vs. CC | 0.73 | 0.90 (0.51–1.60) | NA | NA |
| CC vs. CT + TT | 0.30 | 1.15 (0.88–1.50) | NA | NA |
| CT vs. CC + TT | 0.32 | 0.87 (0.66–1.15) | NA | NA |
| TT vs. CC + CT | 0.85 | 0.95 (0.54–1.66) | NA | NA |
| C vs. T | 0.35 | 1.11 (0.89–1.39) | NA | NA |
| E, Oral carcinoma (n=1a) | ||||
| CC vs. CT | 0.77 | 1.13 (0.49–2.62) | NA | NA |
| CT vs. TT | 0.02 | 1.93 (1.13–3.29) | NA | NA |
| TT vs. CC | 0.06 | 0.46 (0.20–1.03) | NA | NA |
| CC vs. CT + TT | 0.21 | 1.65 (0.76–3.60) | NA | NA |
| CT vs. CC + TT | 0.05 | 1.67 (1.00–2.77) | NA | NA |
| TT vs. CC + CT | 0.006 | 0.50 (0.31–0.82) | NA | NA |
| C vs. T | 0.007 | 1.69 (1.16–2.48) | NA | NA |
| F, Breast cancer (n=1a) | ||||
| CC vs. CT | 0.37 | 1.10 (0.89–1.35) | NA | NA |
| CT vs. TT | 0.10 | 1.79 (0.89–3.58) | NA | NA |
| TT vs. CC | 0.05 | 0.51 (0.26–1.00) | NA | NA |
| CC vs. CT + TT | 0.18 | 1.15 (0.94–1.41) | NA | NA |
| CT vs. CC + TT | 0.47 | 0.93 (0.75–1.14) | NA | NA |
| TT vs. CC + CT | 0.06 | 0.52 (0.27–1.03) | NA | NA |
| C vs. T | 0.08 | 1.17 (0.98–1.40) | NA | NA |
| G, Testicular tumor (n=1a) | ||||
| CC vs. CT | 0.38 | 0.88 (0.67–1.17) | NA | NA |
| CT vs. TT | 0.65 | 1.23 (0.50–3.01) | NA | NA |
| TT vs. CC | 0.85 | 0.92 (0.38–2.21) | NA | NA |
| CC vs. CT + TT | 0.43 | 0.90 (0.69–1.18) | NA | NA |
| CT vs. CC + TT | 0.38 | 1.13 (0.86–1.49) | NA | NA |
| TT vs. CC + CT | 0.80 | 0.89 (0.37–2.14) | NA | NA |
| C vs. T | 0.53 | 0.93 (0.73–1.18) | NA | NA |
| H, Skin cancer (n=1a) | ||||
| CC vs. CT | 0.35 | 0.80 (0.51–1.27) | NA | NA |
| CT vs. TT | 0.56 | 1.45 (0.41–5.08) | NA | NA |
| TT vs. CC | 0.81 | 0.86 (0.26–2.87) | NA | NA |
| CC vs. CT + TT | 0.42 | 0.83 (0.54–1.29) | NA | NA |
| CT vs. CC + TT | 0.33 | 1.25 (0.79–1.98) | NA | NA |
| TT vs. CC + CT | 0.74 | 0.82 (0.25–2.72) | NA | NA |
| C vs. T | 0.54 | 0.88 (0.60–1.31) | NA | NA |
| I, Caucasian (n=4a) | ||||
| CC vs. CT | 0.48 | 1.25 (0.67–2.33) | 66% | 0.03 |
| CT vs. TT | 0.78 | 1.16 (0.41–3.29) | 70% | 0.02 |
| TT vs. CC | 0.67 | 0.78 (0.24–2.51) | 72% | 0.01 |
| CC vs. CT + TT | 0.40 | 1.30 (0.71–2.38) | 70% | 0.02 |
| CT vs. CC + TT | 0.92 | 0.97 (0.55–1.73) | 73% | 0.01 |
| TT vs. CC + CT | 0.68 | 0.80 (0.28–2.27) | 73% | 0.01 |
| C vs. T | 0.45 | 1.23 (0.71–2.13) | 83% | 0.0006 |
| J, Asian (n=3a) | ||||
| CC vs. CT | 0.12 | 1.22 (0.95–1.56) | 0% | 0.77 |
| CT vs. TT | 0.07 | 0.86 (0.72–1.01) | 0% | 0.49 |
| TT vs. CC | 0.35 | 0.83 (0.57–1.22) | 0% | 0.54 |
| CC vs. CT + TT | 0.15 | 1.19 (0.94–1.51) | 0% | 0.58 |
| CT vs. CC + TT | 0.03 | 0.85 (0.73–0.98) | 0% | 0.61 |
| TT vs. CC + CT | 0.17 | 1.12 (0.95–1.32) | 15% | 0.17 |
| C vs. T | 0.81 | 1.03 (0.83–1.26) | 54% | 0.11 |
a
Number of articles. Significant associations are denoted in bold font. OR, odds ratio; CI, confidence interval; NA, not applicable.