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. 2017 Jun 9;16(2):1269–1277. doi: 10.3892/mmr.2017.6751

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Copyright: © Shao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SHH signaling mediates neuroprotection through the PI3K/Akt pathway. (A) Immunohistochemical staining was performed to visualize TH-positive dopaminergic neurons in the SNpc. A1 scale bar=500 µm; A2 scale bar=200 µm; A3 scale bar=400 µm. (B) Number of TH-positive dopaminergic neurons in SNpc. (C) Western blotting and analysis of TH protein. (D) Relative level of TH protein. *P<0.01 compared with control group; **P<0.01 compared with MPTP group; ***P<0.01 compared with PM+MPTP group. TH, Tyrosine hydroxylase.