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. 2017 Jun 22;16(2):1991–2001. doi: 10.3892/mmr.2017.6846

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Copyright: © Yao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Hypoxia decreases osteogenic differentiation. CESCs were induced to differentiate into the osteogenic lineage under normoxic and hypoxic conditions for 21 days. (A) Western blotting and (B) densitometric analysis of the expression of RUNX2 and COL1 in the samples. The protein expression levels were normalized to β-actin. Data are presented as the mean ± standard deviation; n=3/group. *P<0.05. (C) Macrographs of alizarin red and ALP staining in CESCs that were induced under normoxic and hypoxic conditions. CESCs, cartilage endplate-derived stem cells; N, normoxia; H, hypoxia; RUNX2, runt-related transcription factor 2; COL1, collagen type 1; ALP; alkaline phosphatase.