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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: IEEE Trans Biomed Circuits Syst. 2017 May 19;11(3):497–509. doi: 10.1109/TBCAS.2017.2679441

TABLE I.

Comparison and Summary

[19] [16] [24] [25] [11] [12], [13] This work
Application target Peripheral nerve Cortex Cortex Spinal cord (pain reduction) Spinal cord (motor function) Spinal cord (motor function) Spinal cord (motor function)
No. of stim. ch. 4 10 8 4 13 4 160c, 40d, 20e
Stim. mode Current Current Current Voltage Current Current Current
Max current (mA)/resolution (bit) 25/10 4.18/6 0.23/5 10.5Va/8 1/8 10/14 0.5/7c
2/9d
4/10e
Stim. freq. (Hz)/PW (ms) 0.15–8.3k/0.01–12.8 15.4/1 (fixed) 60–220/0.04–0.44 2–150/0.06–0.45 Any, externally defined N/A (0.05–2) Up-to 20k/0.01–8
Residual charge removal No recording design N/A N/A N/A N/A N/A Yes (passive)
No. of recording ch. 4 8 1 (FSCV recording) 16
Gain (dB)/BW (Hz) 54/0.64–6k 60–74/0.5–3K N/A 4062/57k
ADC ENoB (bit) 8 6.5 10 8.5
Noise (μV)/NEF/power (μW/Ch.) 6.3/3.76/16 1.97/2.9/8.6 N/A 7.68/7.64/5.4
Duplex data link N/A N/A N/Ab N/A Yes (bluetooth) Yes
Forward data rate N/A 0.1 0.1 N/A ~0.23 2 (DPSK)
Reverse data rate 0.175 0.8 2 0.0002 ~0.23 2 (LSK)
Impedance characterization N/A N/A N/A N/A N/A 48 Ch.
Power telemetry Yes Yes Yes N/A N/A Yes
Stimulator compliance voltage (V) > 10 5 4.5 >10 25 > 5 ±6 – ±12
CMOS process (nm) 800 HV 180 180 180 180 HV Discrete components 180 HV
Power consumption (mW) N/A 0.468 N/A ~58.08 0.114 N/A ~18
Chip size (mm2) 50 4 7.5 2.4 6.4 N/A 29.5
Implant size (cm3)/weight (g) 3/6 N/A N/A N/A N/A N/A 0.5/0.7
a

[25] only supports voltage-mode stimulation.

b

Stimulation parameters must be programmed before starting wireless recording.

c,d,e

Multiple stimulator outputs can be combined to support large stimulation current.