Table III.
Detailed list of significant DEGs by functional categories from GO analysis.
| Functional category | Significant DEGs |
|---|---|
| Binding (GO:0005488) | EDN3, CXCL5, GBX2, LRRTM4, TMPRSS11D, WFDC5, NR0B1, VWA3B, CELSR3, INHBA, ONECUT2, OLIG2, PROK1, TMPRSS11B, KLK10, KLK7, PTGDS, F10, IL1β, CCL1, ISL1, SPINK5, GDF6, FOXD3, CRNN, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, HOXB13, CCL14, S100A12, IGF2BP2, IL24, CCL18, KLK12, KLK5, BNIPL, TMPRSS2, TNNI3, ESM1, FOXD1, CAMP, SPINK7, PRSS27, WISP2, PGLYRP3, CNGB1, EN2, UPK1A, KLK8, DSG1, PPP1R3C, DAPL1, PGLYRP4, CD1E, TRIO, SIM2, GAS2L3, SALL4 |
| Catalytic activity (GO:0003824) | TMPRSS11D, WFDC5, VWA3B, OLIG2, TMPRSS11B, KLK10, KLK7, PTGDS, F10, KLK11, TMPRSS11F, TMPRSS11E, IGF2BP2, KLK12, KLK5, TMPRSS2, CAMP, SPINK7, PRSS27, KLK8, PPP1R3C, DAPL1, TRIO |
| Enzyme regulator activity | TMPRSS11D, WFDC5, VWA3B, OLIG2, TMPRSS11B, KLK10, KLK7, PTGDS, F10, |
| (GO:0030234) | KLK11, TMPRSS11F, TMPRSS11E, IGF2BP2, KLK12, KLK5, TMPRSS2, CAMP, SPINK7, PRSS27, KLK8, PPP1R3C, DAPL1, TRIO |
| Nucleic acid binding transcription factor activity (GO:0001071) | GBX2, NR0B1, ONECUT2, OLIG2, ISL1, FOXD3, HOXB13, FOXD1, EN2, SIM2, SALL4 |
| Receptor activity (GO:0004872) | LRRTM4, TMPRSS11D, NR0B1, CELSR3, TMPRSS11B, KLK10, KLK7, F10, KLK11, TMPRSS11A KLK9, TMPRSS11F, TMPRSS11E, KLK12, KLK5, TMPRSS2, PRSS27, UPK1A, KLK8 |
| Structural molecule activity (GO:0005198) | TNNI3, GAS2L3 |
| Transporter activity (GO:0005215) | CNGB1 |
| Apoptotic process (GO:0006915) | TMPRSS11D, INHBA, TMPRSS11B, GDF6, KLK11, TMPRSS11A, KLK9 TMPRSS11F, TMPRSS11E, IGF2BP2, PGL, YRP3, DAPL1, PGLYRP4 |
| Biological adhesion (GO:0022610) | LRRTM4, CELSR3, WISP2, UPK1A |
| Biological regulation (GO:0065007) | EDN3, CXCL5, GBX2, LRRTM4, MPRSS11D, WFDC5, NR0B1, VWA3B |
| INHBA, ONECUT2, OLIG2, TMPRSS11B, KLK10, KLK7, F10, IL1B, ISL1, GDF6, FOXD3, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, HOXB13, IL24, KLK12, KLK5, TMPRSS2, FOXD1, CAMP SPINK7, PRSS27, WISP2, CNGB1, EN2, KLK8, PPP1R3C, DAPL1, TRIO, SIM2, SALL4 | |
| Cellular component organization or biogenesis (GO:0071840) | CELSR3 |
| Cellular process (GO:0009987) | EDN3, CXCL5, LRRTM4, CELSR3, INHBA, ONECUT2, PTGDS, IL1B CCL1, GDF6, FOXD3, CRNN, CCL14, S100A12, IGF2BP2, IL24, CCL18, BNIPL, FOXD1, WISP2, CNGB1, UPK1A, DSG1, DAPL1, TRIO, GAS2L3 |
| Developmental process (GO:0032502) | GBX2, LRRTM4, TMPRSS11D, NR0B1, CELSR3, INHBA, ONECUT2, OLIG2, PROK1, TMPRSS11B, ISL1, GDF6, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, HOXB13, IGF2BP2, BNIPL, TMPRSS2, TNNI3, WISP2, PGL, YRP3, EN2, DAPL1, PGLYRP4, SIM2, GAS2L3 |
| Immune system process (GO:0002376) | CXCL5, TMPRSS11D, TMPRSS11B, KLK10, KLK7, PTGDS, F10, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, IGF2BP2, KLK12, KLK5, TMPRSS2, PRSS27, CNGB1, KLK8 |
| Localization (GO:0051179) | CXCL5, TMPRSS11D, TMPRSS11B, KLK10, KLK7, PTGDS, F10, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, IGF2BP2, KLK12, KLK5, TMPRSS2, PRSS27, CNGB1, KLK8 |
| Locomotion (GO:0040011) | CXCL5 |
| metabolic process (GO:0008152) | GBX2, TMPRSS11D, WFDC5, NR0B1, VWA3B INHBA, ONECUT2, OLIG2, TMPRSS11B, KLK10, KLK7, PTGDS, F10, ISL1, GDF6, FOXD3 CRNN, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, HOXB13, S100A12, IGF2BP2, KLK12, KLK5, TMPRSS2, FOXD1, CAMP, SPINK7 PRSS27, PGLYRP3, EN2, KLK8, PPP1R3C, DAPL1 PGLYRP4, TRIO, SIM2. SALL4 |
| Multicellular organismal process (GO:0032501) | TMPRSS11D, ONECUT2, PROK1, TMPRSS11B, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, HOXB13, IGF2BP2, TMPRSS2, TNNI3, UPK1A, TRIO |
| Reproduction (GO:0000003) | F10, HOXB13, TMPRSS2, PRSS27, UPK1A |
| Response to stimulus (GO:0050896) | CXCL5, TMPRSS11D, INHBA, TMPRSS11B, KLK10, KLK7, F10, IL1β, CCL1, GDF6, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, CCL14, S100A12, IL24, CCL18, KLK12, KLK5, TMPRSS2, CAMP, PRSS27, WISP2, CNGB1, UPK1A, KLK8, TRIO |
| Cell part (GO:0044464) | PGLYRP4, TRIO, SIM2, SALL4 |
| Extracellular matrix (GO:0031012) | LRRTM4, WISP2 |
| Extracellular region (GO:0005576) | CXCL5, LRRTM4, TMPRSS11D, INHBA, TMPRSS11B, KLK10, KLK7, F10, IL1β, GDF6, KLK11, TMPRSS11A, KLK9, TMPRSS11F, TMPRSS11E, IL24, KLK12, KLK5, TMPRSS2, PRSS27, WISP2, KLK8 |
| Macromolecular complex (GO:0032991) | IGF2BP2 |
| Membrane (GO:0016020) | CNGB1, DSG1, CD1E |
| Organelle (GO:0043226) | ONECUT2, FOXD3, TNNI3, FOXD1 |
DEGs, differentially expressed genes; GO, gene ontology.