Figure 1.

Protein expression levels of HMGB1, p-p65, RAGE and P-gp in the hippocampus following status epilepticus. Proteins were measured at 6, 12, 24, 48, 72 h, 5 and 7 days after termination of seizures, by western blotting. β-actin served as the loading control. Densitometry analysis was performed and data are presented as mean ± standard deviation. *P<0.05, **P<0.01 and ***P<0.0001. HMGB1, high-mobility group box 1; RAGE, receptor for advanced glycation end-product; p-p65, phosphorylated-NF-κB p65; P-gp, P-glycoprotein.