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. 2017 Jun 9;16(2):1117–1124. doi: 10.3892/mmr.2017.6744

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Immunohistochemical staining for PPAR-γ, TRPC1 and TRPC6 protein expression in lung tissues isolated from newborn control and PPHN model rats. PPAR-γ is expressed in the nucleus and cytoplasm of pulmonary vascular endothelial cells and smooth muscle cells relative immunostaining density for PPAR-γ in pulmonary arterioles in the PPHN group was notably lower compared with the control group. TRPC1 and TRPC6 proteins were expressed in the cytoplasm of the pulmonary smooth muscle cells and pulmonary epithelial cells. Compared with the control group, TRPC1 and TRPC6 protein expressions were greatly increased in the pulmonary arterioles of the PPHN group. Scale bar, 50 µm; red arrows indicate pulmonary arterioles. PPAR-γ, peroxisome proliferator-activated receptor γ; PPHN, persistent pulmonary hypertension of the newborn; TRPC, transient receptor potential cation channel.