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. 2017 Jun 9;16(2):1223–1231. doi: 10.3892/mmr.2017.6734

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Copyright: © Xiong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — ML221 alleviates pain hypersensitivity induced by CCI of the sciatic nerve. The time course of the effects of intrathecal injection of apelin-13 (10 µg) and ML221 (10 µg) on (A) mechanical allodynia and (B) thermal hyperalgesia at 7 days post-CCI. Behavioral tests were performed before CCI surgery (baseline) and prior to (0 h) and 1, 2, 4, 8 and 12 h following ML221 administration. Increasing doses of ML221 (1, 3, 10 and 30 µg) were administered at 7 days post-CCI. (C) Paw withdrawal time and (D) paw withdrawal latency were measured prior to CCI surgery (baseline) and prior to (0 h) and 1, 2, 4, 6 and 8 h following ML221 administration. A total of eight rats were included in each group. Data are presented as the mean ± standard error of the mean. Data were analyzed using two-way analysis of variance. **P<0.01 vs. CCI + DMSO group. CCI, chronic constriction injury; DMSO, dimethyl sulfoxide.