Table II.
Gene ontology analysis of significant genes obtained from the natural language processing analysis.
| A, Cellular component | |||
|---|---|---|---|
| Term | Genes | Count | P-value |
| Mitochondrion | CAT, NOS1, HK1, MPO, BCL2, SOD1, GCK, CYB5R3, ATP5A1, GSR | 10 | 1.50×10−2 |
| Endoplasmic reticulum/Golgi | NOX4, UGT1A1, SGK1, BCL2, PRKG1, PTGS2, HSPA5, EPHX1, ATP7B, POR, CYB5R3, NOS3 | 12 | 1.42×10−2 |
| Additional cytoplasmic organelles | CAT, TNF, MPO, GLA, ATP6AP1, XDH | 6 | 2.13×10−2 |
| Cytosol | CCND1, NR3C1, HK1, BCL2, HSP90AA1, NADK, MDH1 | 7 | 1.32×10−3a |
| Plasma membrane | EGF, L1CAM, SLC6A8, NOX4, VASP, NOS1, ATF4, TNF, UGT1A1, INSR, FPR1, BCL2, EGFR | 21 | 1.00×10−2 |
| Non-structural extracellular | FST, EGF, IL1B, CSF3, F8, TNF, PTH, IFNA1, LPL, LTF, IL6, SOD1 | 17 | 8.03×10−4a |
| Additional cellular components | CCND1, L1CAM, IL1B, AR, NR3C1, SORD, VASP, NOS1, ATF4, TNF, NASP, ESR1 | 43 | 7.67×10−3a |
| B, Molecular function | |||
| Term | Genes | Count | P-value |
| Transcription regulatory activity | AR, NR3C1, ATF4, ESR1, CREM, BCL2, STAT3, PGR, CREB1, SMARCA5, CDKN2A | 11 | 2.15×10−2 |
| Kinase activity | CCND1, INSR, HK1, PGK1, SGK1, PDGFRB, EGFR, PRKG1, GCK, NADK, CDKN2A, IKBKG | 12 | 9.20×10−4a |
| Additional molecular functions | TKT, CCND1, FST, EGF, L1CAM, SLC6A8, AR, CAT, GSS, NR3C1, SORD, NOX4 | 75 | 2.08×10−3a |
| C, Biological process | |||
| Term | Genes | Count | P-value |
| Cell cycle and proliferation | CCND1, FST, EGF, IL1B, AR, CAT, NOX4, TNF, NASP, ESR1, PTEN, ADA | 23 | 4.13×10−8a |
| Transport | IL1B, SLC6A8, NOS1, TNF, NASP, SGK1, ADA, BCL2, SLC2A1, CREB1, NOX1, LTF | 22 | 1.75×10−2 |
| Stress response | CCND1, IL1B, CAT, F8, TNF, MPO, IFNA1, SGK1, ADA, BCL2, STAT3, HSPB1 | 19 | 3.75×10−6 |
| Developmental processes | CCND1, FST, EGF, L1CAM, IL1B, AR, NR3C1, NOX4, CSF3, VASP, TNF, INSR | 41 | 1.21×10−8a |
| Additional metabolic processes | TKT, IL1B, AR, CAT, GSS, NR3C1, SORD, NOX4, NOS1, ATF4, TNF, UGT1A1 | 54 | 3.37×10−12a |
| Cell-to-cell signaling | IL1B, TF, AR, CREB1, IL6, GCK | 6 | 7.59×10−3a |
| Signal transduction | CCND1, FST, EGF, L1CAM, IL1B, AR, CAT, NR3C1, TNF, INSR, PTEN, PLCG1 | 29 | 8.84×10−3a |
| Death | NR3C1, TNF, PTEN, SGK1, ADA, BCL2, HPRT1, IL6, SOD1, IL2, IL10, ALDH1A1 | 14 | 7.66×10−5a |
| Additional biological processes | TKT, CCND1, FST, L1CAM, IL1B, TF, AR, GSS, NR3C1, NOX4, CSF3, NOS1 | 43 | 3.94×10−2a |
a
P<0.01.