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Protein levels of caspase-3 and caspase-8 increase in osteosarcoma cells treated with SK and ADM. Following treatment of the U2OS and MG63 cells with SK and ADM for 48 h, protein levels of caspase-3 and caspase-8 were higher, compared with those in the groups treated with SK or ADM alone. *P<0.05. Ctrl, control; SK, shikonin; ADM, adriamycin; PARP, poly (ADP-ribose) polymerase; BAX, B-cell lymphoma 2-associated X protein.
