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Effect of IMD on sympathetic neural remodeling following myocardial infarction. (A) Representative immunostaining for TH- and GAP43-positive nerve fibers in the peri-infarct zone (magnification, ×400; scale bar=50 µm). Quantification of (B) TH- and (C) GAP43-positive nerve fiber densities. Data are presented as the mean ± standard deviation. *P<0.05 vs. sham group; #P<0.05 vs. HF group. TH, tyrosine hydroxylase; GAP43, growth associated protein 43; IMD, intermedin; HF, heart failure.
