Table 5.
Association of SNPs haplotypes in the OPG, TRAF6, RANKL, and NFATC1 genes with unilateral or bilateral hip lesions of ONFH
| SNPs | Haplotype | Bil▲n(freq) | Unil▼n(freq) | χ2 | P | OR(95%CI) |
|---|---|---|---|---|---|---|
| OPG: rs2073618(G/C) -rs2073617(C/T) |
C-C | 55.00(0.270) | 37.66(0.248) | 0.144 | 0.70 | 1.098 (0.678~1.777) |
| G-C | 36.00(0.176) | 22.34(0.147) | 0.465 | 0.49 | 1.222 (0.687~2.173) | |
| G-T | 113.00(0.554) | 89.66(0.590) | 0.720 | 0.39 | 0.831(0.542~1.275) | |
| TRAF6 : rs5030411(C/T), -rs5030416(C/A) |
C-A | 29.00(0.14) | 21.00(0.13) | 0.012 | 0.91 | 1.034 (0.564~1.894) |
| C-C | 36.00(0.176) | 16.00(0.105) | 3.540 | 0.06 | 1.821 (0.969~3.423) | |
| T-A | 139.00(0.681) | 115.00(0.75) | 2.410 | 0.12 | 0.688(0.429~1.104) | |
| RANKL: rs7984870(G/C) -rs9525641(T/C) -rs1054016(G/T) |
C-C-G | 3.04(0.020) | 5.12(0.047) | 1.661 | 0.19 | 0.399 (0.095~1.687) |
| C-C-T | 68.96(0.442) | 42.88(0.390) | 0.536 | 0.46 | 1.206 (0.730~1.993) | |
| C-T-G | 0.00(0.000) | 2.00(0.018) | _ | _ | _ | |
| G-T-G | 80.96(0.519) | 57.88(0.526) | 0.076 | 0.78 | 0.933 (0.567~1.533) | |
| G-T-T | 2.04(0.013) | 2.12(0.019) | _ | _ | _ | |
| G-C-T | 1.00(0.006) | 0.00(0.000) | _ | _ | _ | |
| Nfatc1: rs754093(G/T), -rs9518(T/C) |
G-C | 14.31(0.072) | 10.58(0.071) | 0.001 | 0.97 | 1.015 (0.445~2.316) |
| G-T | 57.69(0.288) | 39.42(0.263) | 0.282 | 0.59 | 1.137 (0.707~1.829) | |
| T-C | 26.69(0.133) | 10.42(0.069) | 3.703 | 0.05 | 2.063 (0.975~4.367) | |
| T-T | 101.31(0.507) | 89.58(0.597) | 2.842 | 0.09 | 0.692(0.451~1.062) |
▲bilateral hips lesions; ▼unilateral hip lesions