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. 2017 Jun 27;11(9):243–256. doi: 10.1177/1753944717714921

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© The Author(s), 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 10. — Major bleeding in atrial fibrillation patients according to renal function for nonvitamin K antagonist oral anticoagulant and warfarin arms of the phase III trials. Major bleeding event rates (%/year) according to renal function subgroups from the phase III pivotal trials for (a) dabigatran, (b) apixaban, (c) edoxaban and (d) rivaroxaban.^{6–8, 35} Mean CHADS₂ scores are reported for the respective arm from the phase III pivotal trials.

AF, atrial fibrillation; CHADS₂, score for estimating risk of stroke; CrCl, creatinine clearance; VKA, vitamin K antagonist.