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Physiological functions of H2S. Including anti-inflammatory, cytoprotective, anti-oxidative, anti-apoptosis, ATP generation, vasodilatation, and osteoprotective effects, even about crosstalk of miRNAs and H2S. During its osteoprotective processing, H2S stimulate the osteogenic differentiation markers (ALP, BGP, osteopontin) but inhibit osteoblast apoptosis, whereas, H2S could promote apoptosis of osteoclast, and inhibit osteoclast differentiation and maturation.
