Table 5. Scenario analyses compared with base findings.
HIV Vaccine | Dual vaccine | PrEP | VMMC | |||
---|---|---|---|---|---|---|
Discount rate | 0% | Net cost | 4.81 | 14.28 | 13.06 | 12.54 |
QALYs gained | 447.38 | 84.42 | 2 236.88 | 370.65 | ||
ICER | 93.05 | 5.91 | 171.22 | 29.56 | ||
6% | Net cost | 4.80 | 14.31 | 13.03 | 12.51 | |
QALYs gained | 446.76 | 107.58 | 2 254.96 | 385.58 | ||
ICER | 93.10 | 7.52 | 173.05 | 30.82 | ||
Cost | High | Net cost | 4.80 | 14.30 | 13.04 | |
QALYs gained | 532.55 | 193.14 | 2 247.83 | n/a | ||
ICER | 110.92 | 13.50 | 172.41 | |||
Low | Net cost | 4.80 | 14.30 | 13.04 | ||
QALYs gained | 399.66 | 51.73 | 1 723.95 | n/a | ||
ICER | 83.24 | 3.62 | 132.23 | |||
Very low | Net cost | 4.80 | 14.30 | 13.04 | ||
QALYs gained | 373.12 | 23.48 | 1 400.79 | n/a | ||
ICER | 77.71 | 1.64 | 107.44 | |||
Effectiveness | High | Net cost | 4.69 | 15.03 | 13.04 | |
QALYs gained | 426.61 | 99.47 | 2 253.37 | n/a | ||
ICER | 90.97 | 6.62 | 172.83 | |||
Low | Net cost | 4.92 | 13.61 | 10.19 | ||
QALYs gained | 464.96 | 101.02 | 1 869.09 | n/a | ||
ICER | 94.58 | 7.42 | 183.5 | |||
Coverage | High | Net cost | 5.60 | 16.68 | 15.21 | 14.60 |
QALYs gained | 486.72 | 84.23 | 2 557.83 | 371.64 | ||
ICER | 86.89 | 5.05 | 168.16 | 25.45 | ||
Low | Net cost | 2.40 | 7.15 | 6.52 | 6.26 | |
QALYs gained | 321.49 | 148.99 | 1 339.99 | 403.06 | ||
ICER | 133.92 | 20.84 | 205.55 | 64.41 |
One way sensitivity analysis was done to systematically examine the impact of selected variables in the analysis by varying it across a plausible range of values with other variables remaining at their baseline level.
ART: Antiretroviral Therapy; HIV: Human Immunodeficiency Virus; HPV: Human Papillomavirus; Dual Vaccine: HIV and HPV Vaccinations; VMMC: Voluntary Male Medical Circumcision; Prep: Pre-Exposure Prophylaxis