Table 3.
Conventional ROC analysis to distinguish metastasis from haemangioma
| Reader | Technique | Sensitivity | Specificity | ROC-AUC | |||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Gadoxetic acid | 89/104 | 86 % | (77–94 %) | 12/16 | 75 % | (45–100 %) | 0.87 | (0.72–1.00) |
| Gadoxetic acid + gadofosveset | 102/104 | 98 % | (95–100 %) | 16/16 | 100 % | (79–100 %)* | 1.00 | (1.00–1.00) | |
| P value | P=0.0002* | P = 0.125* | P=0.0084* | ||||||
| 2 | Gadoxetic acid | 94/103 | 91 % | (84–98 %) | 11/16 | 69 % | (40–100 %) | 0.92 | (0.87–0.97) |
| Gadoxetic acid + gadofosveset | 102/103 | 99 % | (97–100 %) | 16/16 | 100 % | (79–100 %)* | 1.00 | (1.00–1.00) | |
| P value | P=0.0078* | P=0.063* | P=0.0084* | ||||||
Numbers indicate lesions that were used for calculating the percentages with 95 % confidence intervals (in parenthesis). Sensitivities and specificities are calculated using confidence ratings 0–2 vs 3–4 as the cut-off. Asterisks indicate 95 % confidence intervals or P values that are unadjusted for clusters because GEE models did not attain convergence. P values < 0.05, shown in bold, indicate statistically significant differences
ROC receiver-operating characteristic, AUC area under the curve