Fig 1.

Semiautomatic quantitative assessment of sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) imaging. For each scan, piecewise skeletal registration allowed for localization of osseous uptake. Individual lesions were identified (standardized uptake value [SUV] > 15 g/mL), and nonmalignant uptake was removed before extraction of global metrics. (A) [¹⁸F]NaF PET (left)/CT (right) acquisition. (B) Isolation of skeletal uptake. (C) Segmentation and uptake quantification.