Table 2.
Diagnostic accuracy including sensitivity, specificity, PPV and NPV for different combinations of NMP22® BladderChek, qualitative and quantitative (using the best cutoff of 6.7 ng/ml) UBC® Rapid test, and urine cytology (voided urine and bladder wash). Sensitivities were stratified by tumor grade and tumor stage.
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | AUC (95% CI) | P-value* | |
|---|---|---|---|---|---|---|
| NMP22 + cytology (voided urine) | 32.3 | 100.0 | 100.0 | 67.2 | 0.66 (0.53-0.79) |
0.018 |
| Low-grade | 14.3 | |||||
| High-grade | 50.0 | |||||
| pTa | 12.5 | |||||
| CIS | 66.7 | |||||
| pT1 | 40.0 | |||||
| pT2 | 0.0 | |||||
| NMP22 + cytology (bladder washing) | 38.7 | 100.0 | 100.0 | 69.8 | 0.69 (0.56-0.82) |
0.005 |
| Low-grade | 28.6 | |||||
| High-grade | 50.0 | |||||
| pTa | 25.0 | |||||
| CIS | 66.7 | |||||
| pT1 | 40.0 | |||||
| pT2 | 66.7 | |||||
| UBC qualitative + cytology (voided urine) | 71.0 | 76.7 | 68.8 | 78.6 | 0.74 (0.62-0.85) |
<0.001 |
| Low-grade | 35.7 | |||||
| High-grade | 100.0 | |||||
| pTa | 43.8 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 | |||||
| UBC qualitative + cytology (bladder washing) | 77.4 | 77.3 | 70.6 | 82.9 | 0.77 (0.66-0.88) |
<0.001 |
| Low-grade | 50.0 | |||||
| High-grade | 100.0 | |||||
| pTa | 56.3 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 100.0 | |||||
| NMP22 + UBC qualitative + cytology (voided urine) | 74.2 | 76.7 | 69.7 | 80.5 | 0.75 (0.64-0.87) |
<0.001 |
| Low-grade | 42.9 | |||||
| High-grade | 100.0 | |||||
| pTa | 50.0 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 | |||||
| NMP22 + UBC qualitative + cytology (bladder washing) | 80.6 | 77.3 | 71.4 | 85.0 | 0.79 (0.68-0.89) |
<0.001 |
| Low-grade | 57.1 | |||||
| High-grade | 100.0 | |||||
| pTa | 62.5 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 | |||||
| UBC quantitative + cytology (voided urine) | 71.0 | 81.4 | 73.3 | 79.5 | 0.76 (0.64-0.88) |
<0.001 |
| Low-grade | 42.9 | |||||
| High-grade | 93.8 | |||||
| pTa | 43.8 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 | |||||
| UBC quantitative + cytology (bladder washing) | 74.2 | 81.8 | 74.2 | 81.8 | 0.78 (0.67-0.89) |
<0.001 |
| Low-grade | 50.0 | |||||
| High-grade | 93.8 | |||||
| pTa | 50.0 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 | |||||
| UBC quantitative + NMP22 + cytology (voided urine) | 74.2 | 81.4 | 74.2 | 81.4 | 0.78 (0.66-0.89) |
<0.001 |
| Low-grade | 50.0 | |||||
| High-grade | 93.8 | |||||
| pTa | 50.0 | |||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 | |||||
| UBC quantitative + NMP22 + cytology (bladder washing) | 77.4 | 81.8 | 75.0 | 83.7 | 0.79 (0.69-0.90) |
<0.001 |
| Low-grade | 57.1 | |||||
| High-grade pTa |
93.8 56.3 |
|||||
| CIS | 100.0 | |||||
| pT1 | 100.0 | |||||
| pT2 | 0.0 |