Table 3.
Pilot study on peripheral blood mononuclear cells adrenoceptor mRNA expression
| Central obesity | Ratio Yes/No | ||
|---|---|---|---|
| No | Yes | ||
| n | 5 | 10 | |
| F/M | 2/3 | 8/2 | |
| Age | 31 ± 3 | 40 ± 3 | |
| BMI | 21.1 ± 0.7 | 30.1 ± 2.4 | |
| AR subtype | |||
| α1A | 6.95 x 10-9 ± 1.45 x 10-9 | 6.87 x 10-9 ± 4.63 x 10-10 | 0.99 |
| α1B | 1.11 x 10-7 ± 2.02 x 10-8 | 1.56 x 10-7 ± 3.66 x 10-8 | 1.41 |
| α1D | 7.76 x 10-6 ± 2.09 x 10-6 | 1.1 x 10-5 ± 2.21 x 10-6 | 1.42 |
| α2A | 3.72 x 10-9 ± 2.89 x 10-9 | 5.74 x 10-9 ± 1.47 x 10-9 | 1.54 |
| α2B | not detected | not detected | |
| α2C | 4.39 x 10-9 ± 6.76 x 10-10 | 4.57 x 10-9 ± 3.69 x 10-10 | 1.04 |
| β1 | not detected | not detected | |
| β2 | 7.54 x 10-5 ± 5.98 x 10-5 | 3.14 x 10-5 ± 1.84 x 10-5 | 0.42 |
| β3 | 2.56 x 10-8 ± 5.51 x 10-9 | 2.13 x 10-8 ± 5.51 x 10-9 | 0.83 |
Analysis of AR mRNA expression in peripheral blood mononuclear cells in a subgroup of subjects without and with central obesity selected as those having highest or lowest BMI values. Data are presented as mean ± standard error of the mean (SEM). F/M, female male ratio; BMI, body mass index; AR, adrenoceptor. For details see Methods.