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. 2017 Jul 8;7(11):2806–2821. doi: 10.7150/thno.19081

Figure 2.

Figure 2

Structure of human CatB in complex with DARPin 8h6. (a) Superimposition of complexes between CatB (grey) and DARPins 8h6 (red) and 81 (blue). (b) Close-up of the binding interface (top view) and (c) (side-view). The CatB active site, S65-A77 loop and R85-K86 residues are in yellow, light-green and dark-green, respectively. DARPin 8h6 (left) is shown in red and DARPin 81 (right) in blue. Variable site DARPin residues are shown as sticks. (d) Superimposition of DARPin 8h6-CatB complex with the crystal structure of proCatB (PDB ID 3PBH). In all figures, superimposition was performed using CatB residues 1-254 (mature enzyme numbering). All figures were prepared in PyMOL.