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. 2017 Jul 14;7(11):2924–2939. doi: 10.7150/thno.20094

Figure 2.

Figure 2

Synthesis and radiolabeling of (±)-H3RESCA-HSA with [18F]{AlF}2+. (±)-H3RESCA-TFP ester was conjugated to HSA providing (±)-H3RESCA-HSA. (±)-[18F]AlF(RESCA)-HSA was prepared in high RCY and RCP, as assessed by size-exclusion chromatography (SEC), in less than 30 min (starting after elution of fluorine-18 from the anion exchange QMA cartridge). SEC-radio-chromatogram of purified (±)-[18F]AlF(RESCA)-HSA with a retention time of 28.5 min. HSA = human serum albumin (PDB ID:1E7H), rt = room temperature (20-25°C), RCY = radiochemical yield (calculated based on the amount of radioactivity eluted from disposable desalting column relative to the starting activity of [18F]F-), RCP = radiochemical purity.