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. 2017 Jul 14;7(11):2924–2939. doi: 10.7150/thno.20094

Figure 4.

Figure 4

Synthesis and radiolabeling of (±)-H3RESCA-NbV4m119 with [18F]{AlF}2+. (±)-H3RESCA-TFP ester was conjugated to NbV4m119 providing (±)-H3RESCA-NbV4m119. (±)-[18F]AlF(RESCA)-NbV4m119 was prepared in high radiochemical yield. Purification was accomplished with SEC using 4 Hitrap desalting columns in series, affording highly pure (±)-[18F]AlF(RESCA)-NbV4m119 in less than 35 min (starting after elution of fluorine-18 from the anion exchange QMA cartridge). SEC Radio-chromatogram of purified (±)-[18F]AlF(RESCA)-NbV4m119 eluting with a retention time of 26.9 min. rt = room temperature (20-25 °C), RCY = radiochemical yield (calculated based on the preparative chromatogram and relative to radioactivity of [18F]F-/[18F]{AlF}2+), RCP = radiochemical purity.