. Author manuscript; available in PMC: 2018 Aug 1.

Published in final edited form as: J Cell Biochem. 2017 Apr 18;118(8):2231–2240. doi: 10.1002/jcb.25874

Table 3.

Trabecular bone: μCT and static histomorphometric analysis of the distal femur of 20 week-old Lnk^−/− and WT mice

	MicroCT						Histology

Mice	n	BV/TV (%)	SMI	Tb.Th (mm)	Tb.N (1/mm)	Tb.Sp (mm)	n	BV/TV (%)	N.Ob/ T.Ar	N.Oc/ T.Ar	BFR/TV (μm³/μm²/year)	MAR (μm/day)
C57BL/6 (WT)	38	3.6 ± 0.3	2.7 ± 0.1	0.053 ± 0.002	0.69 ± 0.05	0.34 ± 0.01	12	3.9 ± 0.8	59 ± 13	29 ± 4	346 ± 33	1.8 ± 0.1
Lnk^−/−	18	7.7 ± 0.7^*	2.4 ± 0.1^*	0.048 ± 0.002	1.6 ± 0.1^*	0.25 ± 0.01^*	18	9.8 ± 1.1^*	52 ± 13	48 ± 4^*	264 ± 16^*	1.5 ± 0.1^*

BV/TV, bone volume/tissue volume; SMI, structure model index; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular spacing; BV/TV, bone volume/tissue volume; N.Ob/T.Ar, number of osteoblasts/tissue area; N.Oc/T.Ar, number of osteoclasts/tissue area; BFR/TV, bone formation rate/tissue volume; MAR, mineral apposition rate.

Results are presented as mean ± SEM;

Indicates significant difference compared to WT (p<0.05)