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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Trends Genet. 2017 Jun 29;33(8):566–578. doi: 10.1016/j.tig.2017.06.002

Figure 3.

Figure 3

Components of canonical and variant Polycomb repressive complex I. There are two categories of PRC1 complexes, canonical and variant, which are distinguished by the mutually exclusive incorporation of one of six PCGF paralogs. This family of complexes is biochemically defined by the presence of RING1A/B. Components of canonical PRC1 include RING1A/B, PHC1, and CBX family members and are labeled as either PRC1.2 or PRC1.4 based on incorporation of PCGF2 or PCGF4 respectively. RYBP/YAF2, PCGF and RING1A/B are shared core components of variant PRC1, that are characterized by accessory binding partners, including BCOR, KDM2B, E2F6, RYBP, and AUTS2, and labeled according to the PCGF1, PCGF3, PCGF5 or PCGF6 subunits (PRC1.1, PRC1.3, PRC1.5 and PRC1.6).