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. 2017 Aug 16;13:1744806917726416. doi: 10.1177/1744806917726416

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — The effects of curcumin on abdominal withdrawal reflex (AWR) to colorectal distension in rats treated with DSS. DSS produced increase in AWR score at all intensities of stimuli (20/40/60/80 mmHg). Repetitive oral administration of curcumin dose dependently decreased the AWR score, especially, higher dose of curcumin (60 mg/kg) significantly reduced AWR score at 20, 40, and 60 mmHg (*P < 0.05, ***P < 0.001 vs. saline treatment, two-way ANOVA with Bonferroni’s posttest). Naive: normal control group (n = 7); Saline: DSS + saline group (n = 7); Curcumin: DSS + curcumin (20, 60 mg/kg, n = 8 for each dose).