Skip to main content
. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Eur J Cancer. 2017 May 20;80:39–47. doi: 10.1016/j.ejca.2017.04.013

Figure 3.

Figure 3

A–B) The top two panels show 10x (A) and 20x (B) images from a case with 100% diagnostic agreement with the consensus diagnosis of high grade DCIS. There is obvious central comedo-necrosis present in the center of a duct lined by a proliferation with pleomorphic, hyperchromatic nuclei. C–D) The bottom two panels show 10x (A) and 20x (B) images of an unusual case that had very low diagnostic agreement (7%) with the consensus high-grade DCIS diagnosis. This case lacks necrosis and the nuclei of the proliferation are not as obviously high grade as those shown in A–B. A second duct contains micropapillary structures with a similar cytology (B). The majority of participants recorded a highest order diagnosis of ADH (88%) for this case.