Table 1. Cytogenetic abnormalities, telomere dysfunction, and telomerase expression.
| Cell line | Clonal changes* | No. of clones | Chromosome nos. | TTAGGG-negative ends, mean (range) | Mean telomere fluorescence intensity | ABF, % | hTERT expression† |
|---|---|---|---|---|---|---|---|
| LoVo | 5 | 1 | 48-49 | 1 (0-3) | 302 | 5 | 1.4 |
| DLD1 | 1 | 8 | 45-47/91-94 | 2 (0-5) | ND | 10 | 0.84 |
| HCT116 | 3 | 5 | 44-45/51-63 | 3 (0-7) | ND | 11 | 1.0 |
| HT29 | 21 | >10 | 68-72/136-144 | 3 (0-9) | 202 | 11 | 0.23 |
| SW480 | 22 | >10 | 52-59/88-97 | 15 (5-30) | 95 | 29 | 0.27 |
hTERT, human telomerase reverse transcriptase; ND, not determined.
*
Annotations in stem line karyotype.
†
Relative to HCT116.