Figure 2.

Histological changes in splenic tissue of uninfected, and untreated and treated mice infected with Schistosoma mansoni on day 56 post-infection. (A & B) Uninfected spleen with normal architecture. (C & D) Spleen tissue of mice in S. mansoni infected group, showing splenomegaly, and enlargement of the white pulp indicated by cellular prolifertation, and gradual disappearance of the boundary between white and red pulps. (E&F) Spleen tissue of mice in S. mansoni infected groups treated with 1 mg GNPs/kg b. wt., exhibiting significant improvements in the histological architecture of the spleen, and less tissue damage. (G & H) Spleen of mice in infected group treated with PZQ, showing significant improvements in the spleen tissue with fewer lesions. Sections were stained with hematoxylin and eosin; scale bar = 50 μm.