Fig. 2.

Lattice protein results mirror experimental findings. Shown are average fractions of functional chimeras over 50 replicates using parents sharing 20–80% sequence identity (D = 20, 15, 10, or 5) for a high-ν structure, #1080 (A), and a low-ν structure, #873 (B) (see Supporting Text). Independent fits for ρ and ν are plotted. (Inset) Mutation data for each structure collected from homologs used to construct A and B. Curves show four independent best fits to Eqs. 2 and 3 (see Methods); error bars are ±1 SE.