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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: J Alzheimers Dis. 2016 Sep 6;54(2):679–690. doi: 10.3233/JAD-160532

Fig. 3.

Fig. 3

Comparison of mitochondrial movement parameters in the neuronal process of differentiated non-AD and AD cybrid cells. A, B) The percentage of movable (A) and stationary mitochondria (B) in the processes of cybrid cells. C) Average mitochondrial travel velocity and (D) mitochondrial travel distance were calculated. E, F) AD cybrid cells showed significant decreases in anterograde and retrograde mitochondrial movement compared to non-AD controls. Data were collected from 25 processes of each non-AD or AD cybrid cell line. G) Kymographs generated from the live imaging movies showing non-AD and AD cybrid cells, respectively. In the kymographs, the X axis is mitochondrial position and the Y axis represents the time lapse (0–120 s). Vertical white lines represent stationary mitochondria and diagonal lines represent moving mitochondria. Anterograde movements are from left to right and retrograde movements are from right to left. Scale bars = 10 μm.