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Age-related changes in mitochondrial gene transcripts, mtDNA, and DNA oxidation. (A and B) Abundance of mRNA transcripts encoding COX3 and COX4, respectively, declined with age, n = 74. (C) Abundance of mtDNA by using ND1 gene probe declined with age, n = 74. (D) The level of 8-oxo-dG, relative to 2-deoxyguanisine (dG) increased with age, n = 60.
