Table 3.
Differential regulation of genes involved in necroptosis in WNV- and CHIKV-infected mice (log2fold change).
| Necroptosis | WNV-E vs. Ctrl | WNV-L vs. Ctrl | WNV-L vs. WNV-E | CHIKV-E vs. Ctrl | CHIKV-L vs. Ctrl | CHIKV-L vs. CHIKV-E | |
|---|---|---|---|---|---|---|---|
| Symbol | Entrez gene name | Log2 fold change | Log2 fold change | Log2 fold change | Log2 fold change | Log2 fold change | Log2 fold change |
| CYLD | CYLD lysine 63 deubiquitinase | 0 | 0 | 0 | 0 | −0.90 | 0 |
| MLKL | Mixed lineage kinase domain like pseudokinase | 1.37 | 2.47 | 0 | 0 | 1.98 | 1.63 |
| RIP1 (RIPK1) | Receptor interacting serine/threonine kinase 1 | 0.19 | 1.22 | 1.00 | 0 | 0.62 | 0.69 |
| RIP3 (RIPK3) | Receptor interacting serine/threonine kinase 3 | 0 | 0.52 | 0.46 | 0 | 0.26 | 0.28 |
| CFLAR (C-FLIP) | CASP8 and FADD like apoptosis regulator | 0.38 | 1.78 | 1.40 | 0 | 1.38 | 1.43 |
| FADD | Fas associated via death domain | 0 | 0 | 0 | 0 | 0 | 0 |
| BIRC2 (cIAP1) | Baculoviral IAP repeat containing 2 | 0 | 0.97 | 1.09 | 0 | 0.30 | 0.44 |
| BIRC3 (cIAP2) | Baculoviral IAP repeat containing 3 | 0.59 | 2.64 | 2.05 | 0 | 1.69 | 1.65 |