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. 2017 Aug 17;8:998. doi: 10.3389/fimmu.2017.00998

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Copyright © 2017 Xu, Zhou, Lam and Pang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactions of natural killer (NK) and MCF7 cells in isolated microwells. (A) Microwells of different sizes with NK (red) and MCF7 (green) cells seeded at density of 1.2 × 10⁵ cells/cm². (B) MCF7 cell death ratio and NK cell killing efficiency increased with microwell size. (C) Time for first MCF7 cell death was similar for all microwells. Scattered dots are individual cases of first MCF7 cell death and vertical lines are average values with error bars.