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. 2017 Aug 17;8:998. doi: 10.3389/fimmu.2017.00998

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Copyright © 2017 Xu, Zhou, Lam and Pang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Natural killer (NK) cell cytotoxicity in connected microwells. Results obtained from isolated microwells are listed for comparison. (A) MCF7 and NK cells distributions in microwells connected by 50-µm long, 10-µm wide microchannels. (B) Connection between 50 μm × 50 μm microwells with microwells of larger sizes increased NK cell cytotoxicity. (C) Time for first MCF7 cell death in connected microwells; in 2–50 μm × 50 μm microwells, triggering time was similar to isolated wells; when connected to larger microwells, triggering time of first target cell death in 50 μm × 50 μm microwells was delayed. (D) Proportion of NK cell in different attacking modes for isolated and connected microwells. More NK cells in triggered mode were observed when 50 μm × 50 μm microwells were connected to 100 μm × 100 μm and 150 μm × 150 μm microwells.